PRODUCTS

Product Specification Sheet

> Thrombospondin 1
> Human Alpha Thrombin
> Vitronectin
> HER2-ECD
> CTGF
> EpCAM-ECD
> mPlb2
> hPlb2
> IL6R
> EGFRvIII

Description:

Description:Interleukin-6 (IL-6) mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Ra and gp130. The IL-6Ra chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Ra. IL-6R has a role in various signaling cascades. The gp130 also can transmit signals from leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), interleukin-11 (IL-11) and cardiotrophin-1 (CT-1) in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Ra alone. IL-6Ra is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Ra which consists of only the extracellular domain of the IL-6Ra chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Ra is a 70 kDa protein consisting of the extracellular domain of the IL-6Ra chain (339 amino acid residues).

Source:
- DNA sequence for hn IL6R-ECD (extracellular domain); aa L20-D358
- produced serum free in stable HEK293 cells
- purified from the culture supernatant

Purification:
by affinity chromatography

Formulation:
liquid in PBS, pH 7,4

Concentration:
1000 µg/ml

Purity:
>95% non reduced SDS-PAGE
70-75 kDa band

Identity:
Immuno-Blot with specific antibody

Activity:
tested in apoptosis test of CLL cells

Stability:
at least 12 months at -70 ° C, avoid repeated freeze/thaw cycles

Sizes:
50 µg     100 µg     1000 µg

Cat.No.:
IL6R50     IL6R100     IL6R1000

Usage:
laboratory reagent - not to be used as a diagnostic product or for
administration to humans or used for any drug purposes