PRODUCTS

Product Specification Sheet

> Thrombospondin 1
> Human Alpha Thrombin
> Vitronectin
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> EpCAM-ECD
> mPlb2
> hPlb2
> IL6R
> EGFRvIII

Description: Vitronectin is a multifunctional glycoprotein present in blood and in the extra-cellular matrix. The complete open
reading frame encodes for 459 amino acids which are preceded by a 19 amino acid signal peptide. It contains three
glycosilation sites and its carbohydrate moiety contributes about 30% to this molecular mass.
Vitronectin is an important participant in a large variety of biological functions. These include cell attachment, spreading and
migration, blood coagulation, plasminogen activation, fibrinolysis, and the regulation of complement function.
Recombinant vitronectin appears as multimer compared to the one-chain form in blood. This altered structure may contribute
to different biological activities.

Source:
- original DNA sequence for vitronectin
- produced serum free in a human cell line
- purified from the culture supernatant

Purification:
by affinity chromatography without the use of denaturing agents

Formulation:
- liquid or dried -
- sterile -

Purity:
>95% SDS-PAGE
HMS 800 kDa, reduced dimer at 120 kDa, monomer at 65 kDa

Identity:
Immuno-Blot with specific polyclonal antiserum

Activity:
tested in a cell attachment and spreading assay

Stability:
at least 12 months at -20 ° C
avoid repeated freeze/thaw cycles when dissolved

Sizes:
100 µg     1000 µg

Cat.No.:
VN100     VN1000

Usage:
laboratory reagent - not to be used as a diagnostic product or for
administration to humans or used for any drug purposes

Literature: Seger D., Shaltiel S. (2000) FEBS Lett. 480, 169-174
Schvartz I. et al. (1999) IJBCB 31, 539-544
Suzuki S. et al. (1985) EMBO J. 4, 2519-2524