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PRODUCTS
Product Specification Sheet
Recombinant Human Thrombospondin 1
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Prices:
100 µg
500 µg
1000 µg
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297.00 EUR
1236.00 EUR
2082.00 EUR
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Description: Thrombospondin is a large, trimeric, modular glycoprotein composed of three identical subunits with
1170 amino acids. It is a major constituent of platelets released from its alpha-granules in response to thrombin
stimulation. TSP is also a transient component of extracellular matrix in developing and repairing tissues. TSP is a
multifunctional protein consisting of distinct structural domains. It contains an aminoterminal domain with a heparin-
binding site, a segment that is homologous to the alpha1 chain of type 1 procollagen (PC), three type 1 (properdin)
repeats, three type 2 (EGF-like) repeats, seven type 3 (Ca-binding) repeats and a carboxy-terminal cell-binding domain.
The different segments are assigned to cell attachment, cell movement, modulation of proliferation, platelet
aggregation, modulation of angiogenesis, neurite outgrowth and platelet aggregation.TSP is synthesized and secreted
by platelets, fibroblasts, endothelial cells, smooth muscle cells and tumour cells. It functions in proliferation of cells,
wound healing, angiogenesis and tumorigenesis.
Source:
- original DNA sequence for human TSP 1
- produced serum free in a human cell line
- purified from culture supernatant
Purification:
by affinity chromatograhy and gel filtration
Formulation:
- liquid or dried -
- sterile and non-sterile -
Purity:
>95% SDS-PAGE
non-reduced band at 450 kDa,
Identity:
Immuno-Blot with specific monoclonal IgG
Activity:
tested in functional and cell adhesion assays
Stability:
at least 12 months at -20 ° C, avoid repeated freeze/thaw cycles
Sizes:
100 µg 500 µg 1000 µg
Cat.No.:
TSP100 TSP500 TSP1000
Usage:
laboratory reagent - not to be used as a diagnostic product or for
administration to humans or used for any drug purposes
Literature: Adams J. C., Tucker, R.P. (2000) Dev Dyn 218, 280-99
Lawler J. (2000) Curr Opin Cell Biol 12, 634-40
Albo D. et al. (2000) Br J Cancer 83, 298-306
Bornstein P. (2000) Matrix Biol 19, 555-6 |
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Contact: EMP Genetech · Dr. Franz X. Welser · Straussenlettenstrasse 7b · 85053 Ingolstadt/Germany · Tel. +49 841 3796013
© 2011 EMP-GENETECH . Alle Rechte vorbehalten.
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