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PRODUCTS

Product Specification Sheet

> Thrombospondin 1
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Recombinant Human Thrombospondin 1

Prices:

100 µg
500 µg
1000 µg

 

297.00 EUR
1236.00 EUR
2082.00 EUR

Description: Thrombospondin is a large, trimeric, modular glycoprotein composed of three identical subunits with
1170 amino acids. It is a major constituent of platelets released from its alpha-granules in response to thrombin
stimulation. TSP is also a transient component of extracellular matrix in developing and repairing tissues. TSP is a
multifunctional protein consisting of distinct structural domains. It contains an aminoterminal domain with a heparin-
binding site, a segment that is homologous to the alpha1 chain of type 1 procollagen (PC), three type 1 (properdin)
repeats, three type 2 (EGF-like) repeats, seven type 3 (Ca-binding) repeats and a carboxy-terminal cell-binding domain.
The different segments are assigned to cell attachment, cell movement, modulation of proliferation, platelet
aggregation, modulation of angiogenesis, neurite outgrowth and platelet aggregation.TSP is synthesized and secreted
by platelets, fibroblasts, endothelial cells, smooth muscle cells and tumour cells. It functions in proliferation of cells,
wound healing, angiogenesis and tumorigenesis.

Source:
- original DNA sequence for human TSP 1
- produced serum free in a human cell line
- purified from culture supernatant

Purification:
by affinity chromatograhy and gel filtration

Formulation:
- liquid or dried -
- sterile and non-sterile -

Purity:
>95% SDS-PAGE
non-reduced band at 450 kDa,

Identity:
Immuno-Blot with specific monoclonal IgG

Activity:
tested in functional and cell adhesion assays

Stability:
at least 12 months at -20 ° C, avoid repeated freeze/thaw cycles

Sizes:
100 µg     500 µg     1000 µg

Cat.No.:
TSP100     TSP500     TSP1000

Usage:
laboratory reagent - not to be used as a diagnostic product or for
administration to humans or used for any drug purposes

Literature: Adams J. C., Tucker, R.P. (2000) Dev Dyn 218, 280-99
Lawler J. (2000) Curr Opin Cell Biol 12, 634-40
Albo D. et al. (2000) Br J Cancer 83, 298-306
Bornstein P. (2000) Matrix Biol 19, 555-6

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